______________________________________________________________________________                       

Interim Dean, College of Basic and Applied Sciences

Professor of Chemistry

Director, Biomedical Research (MBRS) Program

Fayetteville State University

1200 Murchison Road

Fayetteville , NC 28301-4297

Phone: (910) 672-1659   FAX:  (910) 672-1083

Email:  jbell@uncfsu.edu

 

Education:

Talladega College, Talladega , AL  B.A.: 1973-1977  Chemistry (Biology minor)

Atlanta University, Atlanta ,GA  Ph.D.: 1982-1987  Chemistry (Biochemistry conc.)

UNC-CH, Chapel Hill , NC        Post-Doc:1987-1990       Biochemistry

 

Research and Professional Experience:

Talladega College , Talladega , AL           MBRS Trainee                     1975-76

Southern Research Institute, B'ham, AL          Assistant Chemist                 1977-78

South Carolina Schools, Beaufort , SC          Teacher                             1978-79

Atlanta University , Atlanta , GA              NRSA/MARC Trainee         1982-86

UNC-Chapel Hill , NC                               Postdoctoral Fellow               1987-90

Natl. Inst. Environmental Health Sciences       Senior Staff Fellow                 1990-92 Research Triangle Park , NC

Natl. Inst. Environmental Health Sciences         Research Biologist            1993(Sum.)

Fayetteville State University, Fay. , NC   Associate Professor               1992-1998

Fayetteville State University, Fay. , NC         Professor                         1998-Pres.

Fayetteville State University                        Program Director,               1993-Pres. Biomedical Research Program

Fayetteville State University                    Interim Dean                               2004-Pres. College of Basic and Applied Sciences  

Academic Leadership and Service:

Fayetteville State University Faculty Senate (1996-98)

Graduate Council (Vice-Chair, 2000-2001)

Research Council

Human and Animal Rights Committee (Chair, 1996-98)

Faculty Development Committee

Grievance Committee (Chair, 1999-2001)

SACS Reaccreditation Self-Study Team (Chair, Graduate Programs Subcommittee)

College of Arts and Sciences Grants Committee (Co-chair, 1999-present)

Department of Natural Sciences Committees (Chair or Co-Chair: Honors and Awards, Graduate Admissions, Faculty Search, New Science Building , Alumni, Long-Range Planning)

Honors/Awards/Recognition:

Þ       "Teacher of the Year, 1999-2000", University, College of Arts and Sciences, and Department of Natural Sciences

Þ       Charter Member, Chancellor's Million Dollar Club for Sponsored Research & Programs 1997

Þ       "Teacher of the Year, 1995-96" and "1996-97", Dept. of Natural Sciences

Þ       "Teacher of the Year, 1995-96", College of Arts and Sciences

Þ       Dept. of Natural Sciences Teacher of the Year Nominee 1993-94 and1994-95

Þ       Excellence in Teaching Award, 1994

Þ       University Enhancement Service Award, 1993

 

Professional Membership Societies:

NIH MBRS/MARC Program Director’s Organization (President 1999-2001)

American Society for Biochemistry and Molecular Biology (Minority Affairs Committee, 1999-2002)

American Association for the Advancement of Science (1982-2000)

Council on Undergraduate Research (Councilor, 1997-99)

Association for Women in Science (North Carolina Triangle, Co-President 1991-92)

North Carolina Consortium for Undergraduate Research

North Carolina Academy of Science

Beta Kappa Chi Scientific Honor Society

Alpha Chi National Honor Society

 

Professional/Consultant Service Activities:

National Institutes of Health/ National Institute of General Medical Sciences : 

·        Minority Access to Research Careers  (MARC) Program Review               

Subcommittee (7/1995-6/99)

·        NIH Minority Pre-doctoral Fellowships Review Panel (4/98)    

·        MBRS Biological and Physiological Sciences Special Emphasis Panel (7/95)

·        MORE Program Ad Hoc Advisory Group (11/94)

·        MARC Review Subcommittee/ Special Reviewer (11/94)

·        MBRS Supplemental Instrumentation Grant Special Review Committee (7/94)

·        MBRS Biological Sciences Grants Review Panel (9/94)

·        National Cancer Institute: Workshop on Specialized Small Grants (4/94)

Spelman College Research Infrastructure at Minority Institutions (RIMI) Program

National Science Foundation: Advisory Panel-Research Experiences for Undergrad. Sites (12/94)

Faculty Sponsor, Glaxo SmithKline Women in Science Scholars Program (1995-present)

Member, N.C. Biotechnology Center 'Historically Minority University Biotechnology Initiative' Program Advisory Panel and Executive Committee Member, Facilities & Infrastructure Review Committee (1995-present)

North Carolina-Louis Stokes Alliance for Minority Participation, Executive Committee (1996- present)

North Carolina State University BRIDGE Program Faculty Liaison and Advisory Board Member (1996-present)

Annual Biomedical Research Conference for Minority Students Planning Committee Member (2000-2001)

PUBLICATIONS:

Ph.D. Dissertation:

“Analysis of the Structural and Kinetic Properties of the Ribonucleotide Reductase from Pseudomonas stutzeri”. (1987) Chemistry Department, Atlanta University , Atlanta , GA.      Advisor:  Dr. Franklin D. Hamilton.

      Manuscripts Submitted or In Preparation

Bell , J.B. “Manganese promotes transversion and frameshift mutagenesis during in vitro DNA synthesis by exonuclease-deficient E coli DNA polymerase I”.

Whitehead, K., Pittman, S. and Bell , J.B. “Lead is a frameshift mutator during in vitro DNA synthesis by exonuclease-deficient E coli DNA polymerase I”.

McGee, D. and Bell , J.B. “Cu2+-induced mutagenicity during in vitro DNA synthesis by exonuclease-deficient E coli DNA polymerase I”.

Burroughs, T.A., Allen, S. A. and Bell , J.B. “Analysis of  Ni2+ -induced mutagenicity during in vitro DNA synthesis by E. coli DNA polymerase I”.

Published Research Journal Articles

Bell, J.B., Eckert, K., Joyce, C., and Kunkel, T.A. “Base Miscoding and strand misalignment errors by mutator Klenow polymerases with amino acid substitutions in the O helix of the fingers subdomain”. (1997) J. Biol. Chem. 272: 7345-7351.

Morrison, A. M., Bell , J. B., Kunkel, T. A., and Sugino, A. “Eukaryotic DNA polymerase amino acid sequence required for 3'-5' exonuclease activity”. (1991) Proc.  Nat'l. Acad. Sci. USA 88: 9473-9477.

Bell, J. B. and Jones, M. E. “Purification and characterization of yeast orotidine 5'- monophosphate decarboxylase overexpressed from plasmid pGU2”. (1991) J. Biol.    Chem. 266: 12662-12667.

Bell, J. B., Jones, M. E., and Carter, C. W. Jr. “Crystallization of yeast orotidine  5'- monophosphate decarboxylase complexed with 1-(5'-phospho- b -D-ribofuranosyl) barbituric acid”. (1991) PROTEINS: Structure, Function, and Genetics 9: 143-151.

Smiley, J. A., Paneth, P. O'Leary, M. H., Bell , J. B., and Jones, M. E. “Investigation of the enzymatic mechanism of yeast orotidine- 5'-monophosphate decarboxylase using   13C kinetic isotope effects”. (1991) Biochemistry 30: 6216- 6223.

Acheson, S. A., Bell , J. B., Jones, M. E., and Wolfenden, R. “Orotidine 5'-monophosphate decarboxylase catalysis: kinetic isotope effects and the state of hybridization of a bound transition state analog”. (1990) Biochemistry 49:3198-3202.

Published Abstracts  in Peer-Reviewed Journals

·        Allen, S.V. and J.B. Bell “The effects of Ni2+ on the fidelity of in vitro DNA synthesis by E. coli DNA polymerase I”. (1995) Journal of the Elisha Mitchell Scientific Society 111(4):37.

·        Bell , J. B. “Mn2+ is a potent mutagen during in vitro DNA gap-filling synthesis”.  (1995) The FASEB  Journal 9 (6):1076. 

·        Bell , J. B., Eckert, K., Joyce, C., and Kunkel, T. A.  “Identification of  antimutator and mutator phenotypes among E. coli DNA polymerase derivatives”. (1994) The FASEB Journal 8(7):423.

·        Burroughs, T.*, Allen, S. A., and Bell , J. B.  “A comparison of the specificity of temperature and Ni2+-induced  mutagenicity”. (1999) Journal of the Elisha Mitchell Scientific Society 115 (3):184.*

·        Ford, J. and Bell , J. B. “Site-directed mutagenesis of Asp96 of yeast orotidine 5’- monophosphate decarboxylase from plasmid pGU2”. (1999) Journal of the Elisha Mitchell Scientific Society 115 (3):182.*

·        Hester , S.D. and J.B. Bell “Fe2+ - induced mutagenic effects during in vitro DNA synthesis”. (1995) Journal of the Elisha Mitchell Scientific Society 111(4):36.

·        Johnson, E. Jr., and Bell , J. B. “Site-directed mutagenesis of the yeast orotidine 5’- monophosphate decarboxylase gene nucleotide sequences encoding Asp91 and Asp96”. (1998) Journal of the Elisha Mitchell Scientific Society 114 (2):16.

·        Locklear-Mariani, G. and Bell , J.B. "Analysis of CdCl2-effect on the fidelity of in vitro DNA synthesis”. (1997) Journal of the Elisha Mitchell Scientific Society 113(2):34.

·        McGee, D. and Bell , J.B. “Analysis of Cu2+ mutagenicity during in vitro DNA synthesis  by E.coli DNA polymerase I”. (1998) Journal of the Elisha Mitchell Scientific Society 114 (2):17.

·        McNeill, C. and J.B. Bell “Optimization of crystallization conditions for native yeast ODCase”. (1995) Journal of the Elisha Mitchell Scientific Society 111(4):38.

·        Minnick, D.T., Bell , J.B., Bebenek, K., Eckert, K.A., Joyce, C.M., and Kunkel, T.A. “Fidelity of mutant derivatives of Klenow fragment DNA polymerase”. (1995) The FASEB Journal 9 (6):1071.

·        Pittman, S. and Bell , J.B. "An analysis of the effect of lead chloride on the fidelity of DNA synthesis". (1997) Journal of the Elisha Mitchell Scientific Society 113(2):35

·        Shivers, R.M. and Bell , J. B.  “Analysis of Co2+ mutagenicity during in vitro DNA synthesis by E.coli DNA polymerase I”. (2001) The FASEB Journal 15 (4): 436.15.*

·        Snead, K.* and Bell, J. B. “Examination of the putative antimutagenic effect of selenium compounds on in vitro DNA synthesis by E. coli DNA polymerase I”  (1999) Journal of the Elisha Mitchell Scientific Society 115 (3):171.*

·        Tyler , Tana and Bell , J.B.  “Analysis of Fe2+ mutagenicity during in vitro DNA synthesis  by E. coli DNA polymerase I”. (1998) Journal of the Elisha Mitchell Scientific Society 114 (2):60.

·        Whitehead, K.D. and Bell , J. B.  “Mutational analysis of the effects of PbCl2 on the fidelity of in vitro DNA synthesis”. (2001) The FASEB Journal 15 (4): 436.12.*

Abstracts of Selected Sponsored Student Presentations (1996-2001)

·        Burroughs, T., Allen, S. A., and Bell , J. B.  “The specificity of  Nickel-induced mutagenesis during in vitro DNA synthesis”. National Minority Research Symposium, November 8-11, 2000 , Washington , DC .

·        Burroughs, T., Allen, S. A., and Bell , J. B.  “Comparison of Ni2+-induced frameshifts in forward and reversion mutation assays “.National Minority Research Symposium, November 10-13, 1999 , Phoenix , AZ.

·        Burroughs, T., Allen, S. A., and Bell , J. B.  “An analysis of the effect of DNA preincubation temperature on the specificity of nickel chloride-induced mutagenicity”. N.C. Academy of Sciences Annual Conference, March 27, 1999 , Elon College, NC .

·        Burroughs, T., Allen, S. A., and Bell , J. B.  “A comparison of the effect of temperature on the specificity of nickel chloride-induced mutagenicity”.  National Minority Research Symposium, November 21-24, 1998 , New York, NY .

·        Burroughs, T., Allen , S.A. , and Bell , J.B. “Analysis of Ni2+ mutagenicity during in vitro DNA synthesis by E. coli DNA polymerase I”. N. C. Academy of Sciences Annual Conference, March 27, 1998, Greensboro, NC;10th  National Conference on Undergraduate Research, April 18-20, 1996, Asheville, NC;  National Minority Research Symposium, November 13-17, 1996, Miami, FL; and 5th Annual National Science Foundation Alliance for Minority Participation, Research Conference, July 24-27, 1997, Las Cruces, NM.

·        Ford, Jermaine and Bell , J.B. “Site-directed mutagenesis if Asp96 of yeast orotidine 5’- monophosphate decarboxylase from plasmid pGU2”. N. C. Academy of Sciences Annual Conference, March 27, 1999 , Elon College , NC .

·        Johnson, E. Jr., and Bell , J. B. “Site-directed mutagenesis of the yeast orotidine 5’- monophosphate decarboxylase gene nucleotide sequences encoding Asp91 and Asp96”. N. C. Academy of Sciences Annual Conference, March 27, 1998, Greensboro, NC; 1998 NC State University BRIDGE/PMADD Symposium, October 30, 1998, Raleigh, NC; National Minority Research Symposium, November 21-24, 1998, New York, NY.

·        Locklear-Mariani, G. and Bell , J.B. "Analysis of CdCl2-effect on the fidelity of in vitro DNA synthesis”. N. C. Academy of Sciences Annual Conference, March 22, 1997 , Durham , NC .

·        McGee, D. and Bell , J.B. “DNA Sequence analysis of Cu2+-induced mutations”. National Minority Research Symposium, November 10-13, 1999 , Phoenix , AZ.

·        McGee, D. and Bell , J.B. “Analysis of Cu2+ mutagenicity during in vitro DNA synthesis  by E.coli DNA polymerase I”. N. C. Academy of Sciences Annual Conference, March 27, 1998, Greensboro, NC; 1998 NC State University BRIDGE/PMADD Symposium, October 30, 1998, Raleigh, NC; National Minority Research Symposium, November 21-24, 1998, New York, NY

·        Pittman, S. and Bell , J.B. "An analysis of the effect of lead chloride on the fidelity of DNA synthesis" . N. C. Academy of Sciences Annual Conference, March 22, 1997 , Durham , NC .

·        Pittman, S. and Bell , J.B. "Mutational analysis of lead chloride induced errors during in vitro DNA synthesis". National Minority Research Symposium, November 13-17, 1996 , Miami , FL.

·        Shivers, R. and Bell , J.B. “Analysis of Co2+ mutagenicity during in vitro DNA synthesis by E.coli DNA polymerase I”. National Minority Research Symposium, November 8-11, 2000 , Washington , DC ; 4th Annual NC-LSAMP Undergraduate Research Conference, April 2000, Winston-Salem, NC ; National Minority Research Symposium, November 10-13, 1999 , Phoenix , AZ

·        Snead, K. and Bell, J.B. “Examination of the putative antimutagenic effect of selenium compounds on in vitro DNA synthesis by E. coli DNA polymerase I”. National  Minority Research Symposium, November 21-24, 1998, New York, NY; NC Academy of Sciences Annual Conference, March 27,1999, Elon College, NCSnead, K. and Bell, J.B. "Cr3+ -induced mutagenesis during in vitro DNA synthesis by E. coli DNA polymerase I” . National Minority Research Symposium, November 13-17, 1996 , Miami , FL.

·        Tatum, E.C. and Bell, J.B. “Analysis of the effect of BaCl2 on the fidelity of in vitro DNA synthesis by Escherichia coli DNA polymerase I” 2001 Annual Biomedical Research Conference for Minority Students, Oct.31-Nov.3, Orlando, FL; 5th  Annual NC-LSAMP Undergraduate Research Conference, April 2001, Greensboro, NC

·        Tyler , Tana and Bell , J.B.  “Analysis of Fe2+ mutagenicity during in vitro DNA synthesis  by E. coli DNA polymerase I”.  2nd Annual NCAMP Undergraduate Research Conference, April 1998, Charlotte , NC ; 6th Annual National Science Foundation Alliance for Minority Participation, Research Conference, July 17-21,1998 ,